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Anti -ERAB (3-hydroxyacyl-CoA Dehydrogenase Type-2, 17-beta-hydroxysteroid Dehydrogenase 10, 17-beta-HSD 10, 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase, 3-hydroxyacyl-CoA Dehydrogenase Type II, Endoplasmic Reticulum-associated Amyloid beta-peptide-binding Prot
Anti -ERAB (3-hydroxyacyl-CoA Dehydrogenase Type-2, 17-beta-hydroxysteroid Dehydrogenase
10, 17-beta-HSD 10, 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase, 3-hydroxyacyl-CoA
Dehydrogenase Type II, Endoplasmic Reticulum-associated Amyloid beta-peptide-binding Prot
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
|
| Mutations in several genes associated with early onset Alzheimer's result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. The longer form of Ab has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3- hydroxyacyl-CoA dehydrogenase type II has been identified. It is expressed at high levels in Alzheimer's disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer's disease. | | | Catalog # | E2291-52E | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 1:100 for 30min at RT | | Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10min followed by cooling at RT for 20min. | | Optimal dilutions to be determined by the researcher. | | Positive Control | U251 cells, Alzheimer’s brain | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa100-116 from human ERAB. | | Specificity | Recognizes human ERAB. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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