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You are here:Home » Antibodies » Abs to Enzymes, Dehydrogenase » Anti -ERAB (3-hydroxyacyl-CoA Dehydrogenase Type-2, 17-beta-hydroxysteroid Dehydrogenase 10, 17-beta-HSD 10, 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase, 3-hydroxyacyl-CoA Dehydrogenase Type II, Endoplasmic Reticulum-associated Amyloid beta-peptide-binding Prot

Anti -ERAB (3-hydroxyacyl-CoA Dehydrogenase Type-2, 17-beta-hydroxysteroid Dehydrogenase
10, 17-beta-HSD 10, 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase, 3-hydroxyacyl-CoA
Dehydrogenase Type II, Endoplasmic Reticulum-associated Amyloid beta-peptide-binding Prot

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Mutations in several genes associated with early onset Alzheimer's result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. The longer form of Ab has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3- hydroxyacyl-CoA dehydrogenase type II has been identified. It is expressed at high levels in Alzheimer's disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer's disease.
Catalog #E2291-52E
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:100 for 30min at RT
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10min followed by cooling at RT for 20min.
Optimal dilutions to be determined by the researcher.
Positive ControlU251 cells, Alzheimer’s brain
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa100-116 from human ERAB.
SpecificityRecognizes human ERAB.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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