Anti -Endoplasmic Reticulum Protein 57, CT (ERp57, GRP58, PDIA3, Protein Disulfide
Isomerase Family A, Member 3 [Homo sapiens], HGNC:4606, ERp60, ERp61, GRP57, HsT17083,
P58, PI-PLC, 58kD Microsomal Protein, Endoplasmic Reticulum P58, Glucose Regulated
Protein,
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH |
|
| ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin | | | (lectin chaperones) via their proline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glucosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7). | | | Catalog # | E2291-75C | | Applications | Suitable for use in Western Blot and Immunoprecipitation, Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot:1:2000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 10F699 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH7.4, in 0.09% sodium azide and 50% glycerol. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Human recombinant ERp57 (GRP58). | | Specificity | Recognizes human ERp57. Species Crossreactivity: bovine, canine, guinea pig, hamster, monkey, porcine, rabbit, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Endoplasmic Reticulum Protein 57, CT (ERp57, GRP58, PDIA3, Protein Disulfide Isomerase Family A, Member 3 [Homo sapiens], HGNC:4606, ERp60, ERp61, GRP57, HsT17083, P58, PI-PLC, 58kD Microsomal Protein, Endoplasmic Reticulum P58, Glucose Regulated Protein, |
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