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You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -ERp57 (PDIA3, Protein disulfide isomerase family A, member 3, 58kD glucose-regulated protein, 58kD microsomal protein, Disulfide isomerase ER-60, ER60, ERp57, ERP57, ERp60, ERP60, ERp61, GRP57, GRP58, HsT17083, p58, P58, PI-PLC, Protein disulfide-isomeras

Anti -ERp57 (PDIA3, Protein disulfide isomerase family A, member 3, 58kD glucose-regulated
protein, 58kD microsomal protein, Disulfide isomerase ER-60, ER60, ERp57, ERP57, ERp60,
ERP60, ERp61, GRP57, GRP58, HsT17083, p58, P58, PI-PLC, Protein disulfide-isomeras

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin
(lectin chaperones) via their proline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glucosylated side chains. ERp57 deletion impairs
posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and
leuteinizing-hormone-releasing hormone in the hippocampus (7).
Catalog #E2291-75M
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9L798
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human ERp57 (GRP58).
SpecificityRecognizes human ERp57 at ~57kD. Species Crossreactivity: monkey, rat, hamster, rabbit, porcine, canine, guinea pig.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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