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Endosulfine alpha (ENSA) Recombinant, Human
Endosulfine alpha (ENSA) Recombinant, Human
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| This protein belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and the gene encoding this protein has been proposed as a candidate gene for type 2 diabetes. | | | Catalog # | E2291-85 | | Species | Homo sapiens | | Source | E. coli | | Primary Sequence (aa) | 121 | | Domain (aa) | Full-length | | Tag/Fusion Partner | T7 Tag | | Applications | Suitable for use in ELISA as an Antigen, Ligand, or Assay Standard. Other applications not tested. | | Quality Control | SDS-PAGE Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months. | | Important note | This recombinant enzyme has NOT been tested with regard to biological activity. | | Source | E. coli | | Purity | Highly purified | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2. No preservative added. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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