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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E RIA

Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms, ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart and liver.
Catalog #	E3098-28
Applications	Suitable for use in ELISA and RIA. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Source	Ascites
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone Type	Monoclonal
Isotype	IgG1
Clone No	1.B.759
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.0, before the addition of glycerol to 40%. No preservative added.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Human Endothelin 1.
Specificity	Recognizes human Endothelin 1. Crossreactivities determined by competitive RIA. Concentrations (pg/tube) to give 50% B/Bo: Endothelin 1 (human) - 20; Endothelin 2 (human) - 2; Endothelin 3 (human) - 1000; Big Endothelin (human) - 2; Endothelin C-terminal hexapeptide - 0; Atrial natriuretic peptide (human) - 0; Angiotensin I - 0; Angiotensin II - 0.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.