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You are here:Home » Antibodies » Abs to Endothelin » Anti -Endothelin 1

Anti -Endothelin 1

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH RIA
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms, ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart and liver.
Catalog #E3098-29B
ApplicationsSuitable for use in Immunohistochemistry and the development of IRMA assays for endothelin ET-1 which as a circulating plasma peptide has been associated with a variety of disease studies such as diabetes, hypertension, cardiogenic shock, acute myocardial infarction and uraemia. Other applications have not been tested.
Recommended DilutionImmunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q2188
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 10mM sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenTissue culture supernatant.
SpecificityRecognizes human endothelin ET-1 (10% crossreactivity with ET-3) and when used in conjunction with anti-endothelin, C-terminal, has a sensitivity of 0.06pmol/l for ET-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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