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You are here:Home » Antibodies » Abs to Endothelin » Anti -Endothelin 1

Anti -Endothelin 1

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH IC RIA
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms, ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart and liver.
Catalog #E3098-29E
Applications
Suitable for use in Immunocytochemistry, Immunohistochemistry, Western Blot and RIA. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 1:300
Immunohistochemistry (Frozen): 1:250
RIA: 1:25,000. Use to concentrate ET-1 in solution, e.g. serum/plasma, milk, urine.
Optimal dilutions to be determined by the researcher.
Positive ControlHuman bowel
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D367
HostMouse
SourceHuman
Concentration~2.5mg/ml
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PurityPurified by affinity chromatography
ImmunogenPurified human ET-1 (endothelin-1)
SpecificityRecognizes human ET-1 (epitope aa8-16). Crossreacts slightly with related peptides. Species Crossreactivity: rat and sheep
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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