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You are here:Home » Antibodies » Abs to Infectious Disease Enterovirus » Anti -Enterovirus 70

Anti -Enterovirus 70

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IF N
The enteroviruses are a genus of (+)ssRNA viruses associated with several human and mammalian diseases. Historically the most significant has been the Poliovirus. Other types are coxsackie and echovirus. Enterovirus are the most common cause of aseptic meningitis and can cause serious disease especially in infants and the immunocompromised. Human enteroviruses (family Picornaviridae) infect millions of people worldwide each year, resulting in a wide range of clinical outcomes ranging from unapparent infection to mild respiratory illness (common cold), hand, foot and mouth disease, acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis. In the United States, enteroviruses are responsible for 30,000 to 50,000 meningitis hospitalizations per year as a result of 30 million to 50 million infections. Serologic studies have distinguished 66 human enterovirus serotypes on the basis of an antibody neutralization test, and additional antigenic variants have been defined within several of the serotypes on the basis of reduced or nonreciprocal cross- neutralization between prototype and variant strains. On the basis of their pathogenesis in humans and experimental animals, the enteroviruses were originally classified into four groups, polioviruses, coxsackie A viruses (CA), coxsackie B viruses (CB), and echoviruses, but it was quickly realized that there were significant overlaps in the biological properties of viruses in the different groups. The more recently isolated enteroviruses have been named with a system of consecutive numbers: EV68, EV69, EV70, and EV71.
Catalog #E3310-05
ApplicationsSuitable for use in Immunofluorescence and Neutralization. Other applications not tested.
Recommended DilutionsImmunofluorescence: 1:250.
Neutralization: <1:16 (Titer)
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No2Q1931
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
PurityPurified
ImmunogenEnterovirus 70 strain J670-71
SpecificityRecognizes and neutralizes all Enterovirus 70 strains. Binds to the P1 protein of Enterovirus 70.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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