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Specifications

Clone Host Grade Applications Monoclonal Mouse Supernatant E IH

Envoplakin is a precursor of epidermal cornified envelop under the plasma membrane of keratinocytes in the outer most layers of epidermis. It is expressed in keratinizing and nonkeratinizing stratified squamous epithelia but not in simple epithelia and non-epithelia. Loss of envoplakin function has been linked to the development of palmoplanter keratosis which is associated with the increased risk of esophegeal cancers.
Catalog #	E3317
Applications	Suitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended Dilution	Immunohistochemistry (Formalin/paraffin): 1:5 for 60 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 min. Detection may require use of a high-sensitivity detection system.
	Optimal dilutions to be determined by the researcher.
Positive Control	Skin
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone Type	Monoclonal
Isotype	IgG1
Clone No	5G96
Host	Mouse
Source	Human
Concentration	Not determined
Form	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, before the addition of glycerol to 40%.
Purity	Tissue culture supernatant
Immunogen	N-terminal region of human envoplakin. Cellular Localization
Specificity	Recognizes human Envoplakin. The epitope is located at the N-terminus.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.