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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -EphB4 (Ephrin type-B receptor 4, HTK, MYK1, Tyro11, TYRO11)

Anti -EphB4 (Ephrin type-B receptor 4, HTK, MYK1, Tyro11, TYRO11)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Eph receptors belong to a family of receptor tyrosine kinases. Both ephrins, the ligands for Eph receptors, and Eph receptors are broadly expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. The interaction of ephrins with the appropriate Eph receptor(s) has been implicated in a wide spectrum of functions in vertebrate morphogenesis, including the accurate migration of embryonic cells, formation of boundaries between structures (i.e. rhombomeres and somites), and the control of cytoskeletal changes which dictate cellular shape and adhesion during development. The EphB4 receptor, also known as Htk, Myk1, Tyro11 and Mdk2, was originally identified in CD34+ cells in the bone marrow and has since also been found in erythroid progenitor cells. The interaction between the EphB4 receptor and its ligand, ephrin B2, is critical for embryonic capillary morphogenesis. Upregulation of the EphB4 receptor has been observed in colon carcinoma, and in endometrial cancer4.
Catalog #E3373-05C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications have not been tested.
Recommended DilutionELISA: 0.1-1ug/ml
Western Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No6A77
HostMouse
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein A chromatography.
ImmunogenRecombinant protein corresponding to the C-terminal sequence of the human EphB4 receptor.
SpecificityRecognizes human EphB4 receptor protein. Reactivity is confirmed with human breast carcinoma cell line MDA-MB-231, and 293 cells carrying an expression vector encoding human EphB4 receptor.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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