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You are here:Home » Antibodies » Antibodies-Receptors » Anti -EGFR (Epidermal Growth Factor Receptor, Receptor Tyrosine-protein Kinase ErbB-1, Proto-oncogene c-ErbB-1, ERBB1) (Biotin)

Anti -EGFR (Epidermal Growth Factor Receptor, Receptor Tyrosine-protein Kinase ErbB-1,
Proto-oncogene c-ErbB-1, ERBB1) (Biotin)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH FC
EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Catalog #E3375-11A1-Biotin
ApplicationsSuitable for use in ELISA, Western Blot, Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:4000
Western Blot: 1:2000
Flow Cytometry: 1:10-1:50
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityStore product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note Applications are based on unconjugated antibody.
Clone TypeMonoclonal
Clone No10i41
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
PurityPurified by Protein G affinity chromatography.
ImmunogenPurified His-tagged EGFR protein (fragment).
SpecificityRecognizes human EGFR.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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