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You are here:Home » Molecular Biology » MB-Growth Factors-Epiregulin » Epiregulin, Recombinant, Human (EREG)

Epiregulin, Recombinant, Human (EREG)


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Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0kD transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0kD mature secreted sequence. Recombinant human Epiregulin is a 6.0kD monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence.
Catalog #E3376-75
Biological ActivityThe ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is 0.3ug/ml in the presence of 15ng/ml of human IGF-II.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ddH2O and carrier protein. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Country of OriginUSA
SourceE. coli
Purity98% by SDS-PAGE and HPLC analyses.
ConcentrationAs reported
FormSupplied as a lyophilized powder with no additives.
Reconstitute in ddH20, carrier protein to 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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