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You are here:Home » Growth Factors, Cytokines » Growth Factors-Epiregulin » Epiregulin, Recombinant, Human (EREG)

Epiregulin, Recombinant, Human (EREG)

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Specifications

Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0kD transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0kD mature secreted sequence. Recombinant human Epiregulin is a 6.0kD monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence.
Catalog #E3376-75A
Biological ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is <2ng/ml, corresponding to a specific activity of 5x10e5units/mg.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, 0.1% BSA or HSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight6kD
SourceE. coli
Purity~97% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug
ConcentrationAs reported
FormSupplied as a sterile-filtered, lyophilized powder from 20mM PBS, pH 7.4 and 130mM sodium chloride. Reconstitute in sterile ddH2O, 01% BSA or HSA to a0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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