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You are here:Home » Antibodies » Antibodies-Lamin, Laminin » Anti -Epiligrin (Laminin 5)

Anti -Epiligrin (Laminin 5)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH IC
Epiligrin, the major component of human keratinocyte extracellular matrix, serves as the preferred integrin ligand for alpha 3 beta 1 in plasma membranes and focal adhesions, and colocalizes with alpha 6 beta 4 in hemidesmosomes. The laminin-5 isoform is abundant in transitional epithelium, stratified squamous epithelia, lung mucosa, and other epithelial glands. Laminin-5 is a heterotrimer consisting of alpha3, beta3, and gamma2 subunits that associate via large helical regions to produce a cruciform-shaped molecule. Laminin-5 is synthesized initially as a 460kD molecule that undergoes specific processing to a smaller form after being secreted into the extracellular matrix. The size reduction is a result of processing the 3 and 2 subunits from 190-200 to 160kD and from 155 to 105kD, respectively.
Catalog #E3385
ApplicationsSuitable for use in Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation and ELISA. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: Acetone fixed tissue
Western Blot: Non-reducing conditions.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
Clone No2Q588
FormSupplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
PurityPurified by Protein A affinity chromatography
ImmunogenHuman keratinocytes
SpecificityRecognizes human epiligrin (laminin 5).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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