Anti -Epithelial Sodium Channel, gamma (ENAC Gamma)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E B |
|
| Tissue acidosis (decrease in pH below the physiological level) that occurs in ischemia, tissue damage or inflammation is accompanied by pain. At the molecular level, H+-gated cation channels are activated by low pH in nociceptive neurons. H+-gated cation channels, members of the NaC/DEG superfamily of Na channels that include amiloride-sensitive epithelial Na+ channel proteins (alpha, beta, and gamma, and delta-ENaC subunits), are expressed in epithelia of the vertebrate kidney, colon, lucolon and other tissues. ENaC-b from various species are ~80% identical, and only ~30% similarity with the ENaC-alpha ENaC-delta (human 638 aa) is expressed mainly in brain, pancreas, testis, and ovary. It is 27-30% homologous with the other ENaCs. It can associate with b, and g ENaC to form a functional channel. | | | Catalog # | E3414-75A | | Applications | Suitable for use in ELISA, Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:5000 | | ELISA: 1:10,000-50,000, control peptide can be used to coat plates at 1ug/ml. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | Not determined | | Form | Supplied as a lyophilized powder from PBS, pH 7.4, 0.05% sodium azide. | | Purity | Serum | | Immunogen | A 14 AA Peptide sequence near the N-terminus of rat ENAC g (1) | | Specificity | Recognizes rat ENAC gamma. Species Sequence Homology: mouse (100%), human (92%), rabbit (80%). No significant homology is detected with ENAC alpha, beta, delta subunits. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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