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You are here:Home » Antibodies » Abs to Ion Channel » Anti -Epithelial Sodium Channel, gamma (ENAC Gamma)

Anti -Epithelial Sodium Channel, gamma (ENAC Gamma)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Tissue acidosis (decrease in pH below the physiological level) that occurs in ischemia, tissue damage or inflammation is accompanied by pain. At the molecular level, H+-gated cation channels are activated by low pH in nociceptive neurons. H+-gated cation channels, members of the NaC/DEG superfamily of Na channels that include amiloride-sensitive epithelial Na+ channel proteins (alpha, beta, and gamma, and delta-ENaC subunits), are expressed in epithelia of the vertebrate kidney, colon, lucolon and other tissues. ENaC-b from various species are ~80% identical, and only ~30% similarity with the ENaC-alpha ENaC-delta (human 638 aa) is expressed mainly in brain, pancreas, testis, and ovary. It is 27-30% homologous with the other ENaCs. It can associate with b, and g ENaC to form a functional channel.
Catalog #E3414-75A
ApplicationsSuitable for use in ELISA, Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:5000
ELISA: 1:10,000-50,000, control peptide can be used to coat plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, pH 7.4, 0.05% sodium azide.
PuritySerum
ImmunogenA 14 AA Peptide sequence near the N-terminus of rat ENAC g (1)
SpecificityRecognizes rat ENAC gamma. Species Sequence Homology: mouse (100%), human (92%), rabbit (80%). No significant homology is detected with ENAC alpha, beta, delta subunits.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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