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Anti -Epstein Barr Virus (EBV), Latent Membrane Protein (Mixed clones) (LMP)
Anti -Epstein Barr Virus (EBV), Latent Membrane Protein (Mixed clones) (LMP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells. | | | Catalog # | E3440-32D1 | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (frozen and paraffin): 1:100-1:200. | | Requires protein digestion pre-treatment of paraffin sections (e.g. trypsin). Optimal dilutions to be determined by the researcher. | | Hybridoma | 3X63-Ag8.653 myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | Mixed clones | | Host | Mouse | | Concentration | Not determined | | Form | Supplied as a lyophilized powder, 15mM Sodium Azide. Reconstitute with 1ml ddH2O. | | Purity | Supernatant | | Immunogen | Recombinant fusion protein of bacterial beta-galactosidase and EBV LMP-1 | | Specificity | A cocktail of 4 antibodies recognizing different epitopes of Epstein Barr Virus LMP. This product stains EBV positive lymphoblastoid cell lines and EBV infected B cells in infectious mononucleosis. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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