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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB2 (c-erbB2, HER2, neu Oncoprotein)

Anti -ErbB2 (c-erbB2, HER2, neu Oncoprotein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
ErbB2 (also known as Her2 or neu) is a 185kD transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Tyrosine 1248 within the cytoplasmic domain of the receptor is an auto-phosphorylation site that allows binding of Shc and activation of the Ras, Raf, ERK1&2 signaling pathway.
Catalog #E3451-25J
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in TBS, pH 7.2, 0.1% BSA, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope recognized maps to a region between residues 975 and 1025 of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 using the numbering given in entry NP_004439.2 (GeneID 2064).
SpecificitySpecies Crossreactivity: This antibody crossreacts with human. In initial tests of lysate from mouse NIH3T3 cells, mouse ErbB2 was not readily detectable. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesC-ERBB-2, EC=2.7.10.1, ERBB2, HER-2, HER-2/NEU, NEU, NGL, P185ERBB2, TKR1


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