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Anti -ErbB2 (c-erbB2, HER2, neu Oncoprotein)
Anti -ErbB2 (c-erbB2, HER2, neu Oncoprotein)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Purified |
B IP IH |
|
| Human Her2/neu (also known as c-erbB-2) proto-oncogene is expressed at the cell surface of a range of tumor cells. It is an essential component of a neuregulin-receptor complex, althought neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin. In many types of tumor Her2/neu expression is related to poor prognosis, with an increased risk of metastasis. | | | Catalog # | E3451-25N | | Applications | Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: For paraffin sections, antigen retrieval is not needed but it may optimiz staining. Also good with frozen sections. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 8k92 | | Host | Rat | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide. | | Purity | Purified | | Immunogen | Recombinant full length human ErbB2. Cellular Localization: Cell Membrane | | Specificity | Recognizes epitope E of human ErbB2 (CD340) at ~77kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | C-ERBB-2, EC=2.7.10.1, ERBB2, HER-2, HER-2/NEU, NEU, NGL, P185ERBB2, TKR1 |
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