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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB2 (c-erbB2, HER2, neu Oncoprotein)

Anti -ErbB2 (c-erbB2, HER2, neu Oncoprotein)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified B IP IH
Human Her2/neu (also known as c-erbB-2) proto-oncogene is expressed at the cell surface of a range of tumor cells. It is an essential component of a neuregulin-receptor complex, althought neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin. In many types of tumor Her2/neu expression is related to poor prognosis, with an increased risk of metastasis.
Catalog #E3451-25N
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: For paraffin sections, antigen retrieval is not needed but it may optimiz staining. Also good with frozen sections.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No8k92
HostRat
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified
ImmunogenRecombinant full length human ErbB2. Cellular Localization: Cell Membrane
SpecificityRecognizes epitope E of human ErbB2 (CD340) at ~77kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesC-ERBB-2, EC=2.7.10.1, ERBB2, HER-2, HER-2/NEU, NEU, NGL, P185ERBB2, TKR1


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