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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, p185erbB2, CD340, HER2, HER-2, HER-2/neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, MLN19, NEU, NGL, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, TKR1, Tyrosine Kinase-type Cell Surface Receptor HER2)

Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, p185erbB2, CD340, HER2, HER-2,
HER-2/neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, MLN19, NEU, NGL, Proto-oncogene
Neu, Proto-oncogene c-ErbB-2, TKR1, Tyrosine Kinase-type Cell Surface Receptor HER2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
A novel v-erb-B-related gene, c-erb-B-2, which has been identified in the Human genome, maps to Human chromosome 17 at q21, encodes a polypeptide with a kinase domain. The c-erb-B-2 gene is conserved in vertebrates. Its over-expression is sometimes involved in the neoplastic process. It is an essential component of a neuregulin-receptor complex. Alternative splicing results in several additional transcript variants. It has no ligand binding domain of its own but it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways.
Catalog #E3451-25T
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:25-1:50
Optimal dilutions to be determined by the researcher.
Positive ControlBreast carcinoma
Cellular Localization
Cell membrane
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to human c-erbB-2 oncoprotein (KLH).
SpecificityRecognizes human c-erbB-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=2.7.10.1, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)


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