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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, p185erbB2, CD340, HER2, HER-2, HER-2/neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, MLN19, NEU, NGL, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, TKR1, Tyrosine Kinase-type Cell Surface Receptor HER2)

Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, p185erbB2, CD340, HER2, HER-2,
HER-2/neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, MLN19, NEU, NGL, Proto-oncogene
Neu, Proto-oncogene c-ErbB-2, TKR1, Tyrosine Kinase-type Cell Surface Receptor HER2)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
ERBB2 encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases and it maps to Human chromosome 17 at q21. ERBB2 bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways. Amplification or over expression of ERBB2 results in numerous cancers, including breast and ovarian tumors. Alternative splicing results in two isoforms; 1 and 2. ERBB2 is expressed in Human fetus, mammary gland and ovary.
Catalog #E3451-25U
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlBreast carcinoma, neoplastic cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the cytoplasmic domain of human ERBB2.
SpecificityRecognizes human ERBB2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=2.7.10.1, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)


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