Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, p185erbB2, CD340, HER2, HER-2,
HER-2/neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, MLN19, NEU, NGL, Proto-oncogene
Neu, Proto-oncogene c-ErbB-2, TKR1, Tyrosine Kinase-type Cell Surface Receptor HER2)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
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| ERBB2 encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases and it maps to Human chromosome 17 at q21. ERBB2 bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways. Amplification or over expression of ERBB2 results in numerous cancers, including breast and ovarian tumors. Alternative splicing results in two isoforms; 1 and 2. ERBB2 is expressed in Human fetus, mammary gland and ovary. | | | Catalog # | E3451-25U | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Breast carcinoma, neoplastic cells | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the cytoplasmic domain of human ERBB2. | | Specificity | Recognizes human ERBB2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=2.7.10.1, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) |
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Download Specifications for Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, p185erbB2, CD340, HER2, HER-2, HER-2/neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, MLN19, NEU, NGL, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, TKR1, Tyrosine Kinase-type Cell Surface Receptor HER2) |
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