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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB2, phosphorylated (Tyr1248) (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)

Anti -ErbB2, phosphorylated (Tyr1248) (Receptor Tyrosine-protein Kinase erbB-2, Metastatic
Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine
Kinase-type Cell Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
HER2 has been implicated in numerous functions including normal and aberrant development in a variety of tissues. It is a ligand-less tyrosine kinase receptor of the ErbB family that is frequently overexpressed in breast cancer. It has been shown that HER2 undergoes proteolytic cleavage resulting in the release of the extracellular domain and the production of a phosphorylated membrane bound domain.
Catalog #E3451-26S
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human HER2 around the phosphorylation site of tyrosine1248 (P-E-YP-L-G).
SpecificityRecognizes human HER2, phosphorylated at Tyr1248. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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