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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)

Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19
Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell
Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The ErbB-2 (HER-2/neu) proto-oncogene encodes a 185kD transmembrane receptor protein. It has partial homology with the epidermal growth factor (EGF) receptor and shares intrinsic tyrosine kinase activity with the receptor. ErbB-2 heterodimerizes with the EGF receptor, ErbB-3 receptor, and the ErbB-4 receptor. In human breast and ovarian cancers the receptor is activated through amplification and over-expression of the wild-type gene. This alteration occurs in 25%-30% of cases and is associated with a poor prognosis. The poor prognosis of ovarian and breast cancer patients associated with ErbB-2-mediated high rate of tumor cell proliferation. ErbB-2 may play a role in the genesis of human gastric, endometrial and salivary gland cancers. The concentration of ErbB-2 protein in serum can be a sensitive indicator for prognosis of the gastric carcinoma that expressed ErbB-2. ErbB-2 oncoprotein is detectable in adenocarcinomas as well as in transitional cell carcinomas.
Catalog #E3451-27T
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide (TAENPEYLG) corresponding to the C-terminus of human c-erbB-2 surrounding tyrosine residue 1222.
SpecificityRecognizes human c-erbB-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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