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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)

Anti -ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19
Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell
Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH IF
A tyrosine kinase receptor in the EGF-receptor family. ErbB2 does not bind ligand on its own, but acts as an amplifier in heterodimers with ErbB1, (EGFR), ErbB3, or ErbB4. Amplification of the ErbB2 gene and overexpression of ErbB2 protein is associated with breast cancer (~25% of cases), and anti-ErbB2 therapeutics (e. g. Herceptin, an anti-ErbB2 monoclonal antibody) are sometimes effective in treating these cases. Overexpression of ErbB2 has also been indicated as a factor in prostate cancer.
Catalog #E3451-27W
ApplicationsSuitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 10ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No4E1
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant corresponding to human ERBB2.
SpecificityRecognizes human ERBB2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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