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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB3 (ERBB3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 avian, HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3) (BSA & Azide Free)

Anti -ErbB3 (ERBB3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 avian,
HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3)
(BSA & Azide Free)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP FC IF
c-erbB-3/HER-3 is the third member of the type I family of growth factor receptors. It binds to ligands in the heregulin family. c-erbB-3 is over-expressed in a variety of tumors including breast, stomach, pancreas, and colon. Heregulin & EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
Does not block the binding of heregulin to c-erbB-31, has no effect on tyrosine kinase activity1, receptor internalization1, or tumorigenic growth of cells overexpressing the cerbB- 32.
Catalog #E3451-35BX
ApplicationsSuitable for use in Flow Cytometry, Immunofluorescence, Immunoprecipitation, Effect on Heregulin (NDF) Binding (Non-inhibitory) and Effect on Tumor Growth (Non-inhibitory). Not suitable for Western Blot. Other applications not tested.
Recommended DilutionsImmunoprecipitation: 2ug/mg protein lysate. Use Protein A. Well suited for Immunoprecipitation of unoccupied as well as occupied receptor.
Optimal dilutions to be determined by the researcher.
Positive Control T47D cells.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol 40-50%, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No3F162
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4. Also available with BSA and azide. See E3451-35B
PurityPurified by Protein A affinity chromatography.
ImmunogenExtracellular fragment of recombinant human c-erbB-3/HER-3 oncoprotein. MW of Antigen
SpecificityRecognizes human ErbB3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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