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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB3 (ERBB3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 avian, HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3)

Anti -ErbB3 (ERBB3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 avian,
HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP FC IF
c-erbB-3/HER-3 is the third member of the type I family of growth factor receptors. It binds to ligands in the heregulin family. c-erbB-3 is over-expressed in a variety of tumors including breast, stomach, pancreas, and colon. Heregulin & EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
Catalog #E3451-35C
ApplicationsSuitable for use in Flow Cytometry, Immunofluorescence, Immunoprecipitation, Effect on Tumor Growth and Inhibition of heregulin binding. Not suitable for use in Western Blot. Other applications have not been tested.
Recommended DilutionsInhibition of Heregulin (NDF) Binding: 10ug/ml (Use antibody without sodium azide)
Immunoprecipitation: 2ug/mg protein lysate (Use Protein G)
Effect on Tumor Growth: Non-inhibitory
Optimal dilutions to be determined by the researcher.
Positive ControlT47D
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No3F163
HostMouse
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See E3451-35CX.
PurityPurified by Protein G affinity chromatography.
ImmunogenExtracellular domain of recombinant human c-erbB-3/HER-3 oncoprotein. Epitope: Extracellular domain
Cellular LocalizationCytoplasmic and cell membrane
MW of Antigen185kD
SpecificityRecognizes human c-erbB-3/HER-3. Particularly well suited for inhibiting the binding of heregulin (NDF) to c-erbB- 3/HER-3 and for immunoprecipitating the unoccupied receptor. Does not affect tumorigenic growth of cells overexpressing cerbB- 3. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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