Anti -ErbB3 (ERBB3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 avian,
HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
IP FC IF |
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| c-erbB-3/HER-3 is the third member of the type I family of growth factor receptors. It binds to ligands in the heregulin family. c-erbB-3 is over-expressed in a variety of tumors including breast, stomach, pancreas, and colon. Heregulin & EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. | | | Catalog # | E3451-35C | | Applications | Suitable for use in Flow Cytometry, Immunofluorescence, Immunoprecipitation, Effect on Tumor Growth and Inhibition of heregulin binding. Not suitable for use in Western Blot. Other applications have not been tested. | | Recommended Dilutions | Inhibition of Heregulin (NDF) Binding: 10ug/ml (Use antibody without sodium azide) | | Immunoprecipitation: 2ug/mg protein lysate (Use Protein G) | | Effect on Tumor Growth: Non-inhibitory | | Optimal dilutions to be determined by the researcher. | | Positive Control | T47D | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | N/A | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 3F163 | | Host | Mouse | | Source | Human | | Concentration | ~0.2mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See E3451-35CX. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Extracellular domain of recombinant human c-erbB-3/HER-3 oncoprotein. Epitope: Extracellular domain | | Cellular Localization | Cytoplasmic and cell membrane | | MW of Antigen | 185kD | | Specificity | Recognizes human c-erbB-3/HER-3. Particularly well suited for inhibiting the binding of heregulin (NDF) to c-erbB- 3/HER-3 and for immunoprecipitating the unoccupied receptor. Does not affect tumorigenic growth of cells overexpressing cerbB- 3. Species Crossreactivity: mouse | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -ErbB3 (ERBB3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 avian, HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3) |
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