You are here:Home
»
Antibodies
»
Abs to Oncoproteins
»
Anti -ErbB3, NT (Receptor Tyrosine-protein Kinase erbB-3, Proto-oncogene-like Protein c-ErbB-3, Tyrosine Kinase-type Cell Surface Receptor HER3, HER3)
Anti -ErbB3, NT (Receptor Tyrosine-protein Kinase erbB-3, Proto-oncogene-like Protein
c-ErbB-3, Tyrosine Kinase-type Cell Surface Receptor HER3, HER3)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH FC |
|
| ErbB3, a member of the EGF receptor family, binds and is activated by neuregulins and NTAK. It potentially forms a heterodimer with each of the other ERBB receptors. This protein is predominantly expressed in epithelial tissues and brain. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. Ligand-binding may increase phosphorylation on tyrosine residues and promote its association with the p85 subunit of phosphatidylinositol 3-kinase ErbB3 is overexpressed in a subset of human mammary tumors. | | | Catalog # | E3451-35N | | Applications | Suitable for use in ELISA, Western Blot, Flow Cytometry, and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:100-1:500 | | ELISA: 1:1,000 | | Immunohistochemistry: 1:50-1:100 | | Flow Cytometry: 1:10-1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide selected from the N-terminal region of human ErbB3 (KLH). | | Specificity | Recognizes human ErbB3. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
