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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified IH

c-erbB-4 is the fourth member of class I receptor kinase family (ErbB). HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB-330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Catalog #	E3451-40C
Applications	Suitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions	Optimal dilutions to be determined by the researcher.
Positive Control	Breast carcinoma or skeletal muscle.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG2b
Clone No	3F168
Host	Mouse
Source	Human
Concentration	~0.2mg/ml
Form	Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See E3451-40CX
Purity	Purified by Protein A affinity chromatography.
Immunogen	Synthetic peptide corresponding to aa1249-1264, Cys-RSTLQHPDYLQEYST from the human c-erbB-4/HER-4 oncoprotein. MW of Antigen
Cellular Localization	Cytoplasmic and cell membrane
Specificity	Recognizes human ErbB4. Species Crossreactivity: mouse
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.