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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E

c-erbB-4 is the fourth member of class I receptor kinase family (ErbB). HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB- 330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Catalog #	E3451-40E
Applications	Suitable for use in ELISA. Other applications have not been tested.
Recommended Dilutions	Optimal dilutions to be determined by researcher.
Positive Control	T47D or MDA-MB-453 cells.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA and 0.09% sodium azide. Also available without BSA and azide at 1mg/ml.
Purity	Purified by Protein A affinity chromatography.
Immunogen	A synthetic peptide corresponding to aa1285-1308 from the C-terminus of human c-erbB-4/HER-4 oncoprotein. Cellular Localization: Cytoplasmic and cell membrane.
Specificity	Recognizes human c-erbB4. Species Crossreactivity: mouse and rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.