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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB4, CT (c-erbB4, HER4)

Anti -ErbB4, CT (c-erbB4, HER4)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IC FC
erbB4/HER4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).
Catalog #E3451-40G
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Flow Cytometry, Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:4,000
Immunoprecipitation: 1:100
Flow Cytometry: 1:40
Immunocytochemistry: 1:50
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k165
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to C-terminus (cytoplasmic domain) of human ErbB4
SpecificityRecognizes human ErbB4 at 185kD. Does not cross-react with other EGF receptor family members. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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