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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -ErbB4, phosphorylated (Y1284) (Receptor Tyrosine-protein Kinase erbB-4, Proto-oncogene-like Protein c-ErbB-4, p180erbB4, Tyrosine Kinase-type Cell Surface Receptor HER4, ERBB4)

Anti -ErbB4, phosphorylated (Y1284) (Receptor Tyrosine-protein Kinase erbB-4,
Proto-oncogene-like Protein c-ErbB-4, p180erbB4, Tyrosine Kinase-type Cell Surface
Receptor HER4, ERBB4)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC FC
ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The ErbB4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif, known as the PDZ domain (3).
Catalog #E3451-41T
ApplicationsSuitable for use in Flow Cytometry, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:10-1:100
Western Blot: 1:1000-1:10,000
Immunocytochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No10J101
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenPhospho specific peptide corresponding to residues surrounding Tyrosine 1284 of human ErbB4.
SpecificityRecognizes human ErbB4 at ~180kD only when phosphorylated at Tyrosine 1284. Species Crossreactivity: mouse, rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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