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Erythropoietin, Recombinant, Human (EPO)
Erythropoietin, Recombinant, Human (EPO)
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| Human erythropoietin (EPO) is an acidic glycoprotein. It is mainly produced by the kidney. As the primary regulator of the production of red cells, its major functions are to promote erythroid progenitor cells differentiation and to start the synthesis of hemoglobin. EPO acts by binding to a specific erythropoietin receptor (EPOR) on target cells; the red cell precursors in the bone | | | marrow, and induces their transformation into mature erythrocytes. The EPO sensitivity increases with differentiation of immature progenitor cells. EPO may act as a neuron protector against glutamate toxicity. Its neuroprotective activity comes into effect by neutralizing the toxicity of free radicals. EPO is produced in brain after oxidative stress. EPO is upregulated by hypoxia and prevents apoptosis of erythroid progenitors in bone marrow. EPO has also angiogenic properties. Erythropoietin (EPO) is a glycoprotein hormone produced primarily by the kidney and is the mainfactor regulating red blood cell production. The mature protein consists of a 165 amino acid | | | polypeptide chain heavily glycosylated at three N-linked and O-linked glycosylation sites yielding atotal molecular mass of 35-45kD. About 40% of the fully glycosylated EPO molecule consists of carbohydrate. | | | Catalog # | E3455-07C | | Source | CHO cell | | Specific Activity | 1.8×10e5 units/mg | | Endotoxin | 0.02EU/mg (LAL) | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with sterile ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 1 month at 4 °C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | ~39kD | | Source | CHO cell | | Purity | 95% as determined by SDS-PAGE and HPLC. | | Form | Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 50ug of HSA per 1ug of cytokine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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