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You are here:Home » Antibodies » Abs to Receptors, Estrogen » Anti -Estrogen Receptor, beta (ERb, ER-beta, Nuclear Receptor Subfamily 3 Group A Member 2, ESR2, ESTRB, NR3A2)

Anti -Estrogen Receptor, beta (ERb, ER-beta, Nuclear Receptor Subfamily 3 Group A Member
2, ESR2, ESTRB, NR3A2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Estrogen Receptor (ER) exists in two types: alpha and beta. They are similar in structure. The ligand binding domain and the DNA binding domain are highly conserved in these proteins while the N-terminal transactivating domain is considerably diverged. Five isoforms of the hER beta gene, designated hER b 1-5 have been identified. ER-b binds to estrogen and activates the gene through direct interaction with estrogen specific gene elements (ERE's). ER-b RNA has been detected in human thymus, spleen, ovary and testis and in rat ovary and prostrate. The tissue distribution overlaps but is not identical to that of ER-a RNA. ER-b knock out mice show severe infertility.
Catalog #E3558-40C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Positive ControlMCF-7 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.02% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the N-terminus of human Estrogen Receptor beta.
SpecificityRecognizes human Estrogen Receptor beta. Species Crossreactivity: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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