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You are here:Home » Antibodies » Abs to Receptors, Estrogen » Anti -Estrogen Receptor, alpha (ERa)

Anti -Estrogen Receptor, alpha (ERa)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP
Estrogen Receptor alpha is a 65kD protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha can positively or negatively regulate gene transcription.
Catalog #E3565-09Z
Cellular Localization Nuclear
Positive Control MCF-7 whole cell lysate.
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
Form0.02% Sodium Azide; PBS. pH 7.4
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: GGRERLASTNDK, corresponding to amino acids 160-171 of Human Estrogen Receptor (alpha).
SpecificitySpecies Crossreactivity: Crossreacts with Human. Expected to crossreact with canine (91% identity with immunogen), Goat (91% identity with immunogen), porcine (91% identity with immunogen), Sheep (91% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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