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You are here:Home » Antibodies » Abs to Receptors, Estrogen » Anti -Estrogen Receptor, beta (Erb, ER-beta, ER-BETA, ESRB, ESR-BETA, ESTRB, Estrogen receptor beta, NR3A2, Nuclear receptor subfamily 3 group A member 2)

Anti -Estrogen Receptor, beta (Erb, ER-beta, ER-BETA, ESRB, ESR-BETA, ESTRB, Estrogen
receptor beta, NR3A2, Nuclear receptor subfamily 3 group A member 2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER and ER , contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER and ER have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER and ER may be regulated by distinct mechanisms even though they share many functional characteristics.
Catalog #E3565-15C
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:2000
Optimal dilutions to be determined by the researcher.
Positive ControlMCF7 cell extracts
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H235
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.05% sodium azide.
PurityTissue culture supernatant
ImmunogenSynthetic peptide corresponding to aa63-82 of rat and mouse estrogen receptor b and aa55-74 of human estrogen receptor b, conjugated to KLH. Cellular Localization: Nucleus.
SpecificityRecognizes human estrogen receptor b, long form. It does not detect estrogen receptor alpha. Species sequence homology: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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