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You are here:Home » Antibodies » Abs to Receptors, Estrogen » Anti -Estrogen Receptor, beta (ERb)

Anti -Estrogen Receptor, beta (ERb)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH IF
The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domains have diverged significantly. Similar in function to ER-alpha, ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).
Catalog #E3565-16T
Positive Control Recombinant fusion protein.
ApplicationsSuitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No8k124
HostMouse
SourceHuman
Concentration~1mg/ml
FormAs reported
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant 6-His fusion protein encoding amino acids 1-153 of human ER-beta expressed in E. coli.
SpecificitySpecific for human Estrogen receptor-Beta.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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