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You are here:Home » Antibodies » Antibodies-Receptors, Estrogen » Anti -Estrogen Receptor, beta (ERb)

Anti -Estrogen Receptor, beta (ERb)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Estrogen receptor (ER) was first cloned in 1987 and has been shown to be expressed and transcriptionally active in a number of tissues including ovary, testis, prostate and brain. Until recently, only the "classical" ER (ER alpha) has been known. However, a new estrogen binding receptor, referred to as ER beta, has recently been cloned in rat and humans.
ER beta has been shown to be a high affinity estrogen binding protein capable of initiating transcription of genes under the control of estrogen response elements (ERE)
Catalog #E3565-16Z
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 2-5ug/ml. Perform heat mediated antigen retrieval using citrate buffer.
Immunohistochemistry (Frozen): 2-5ug/ml
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by Immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa459-477, CSPAEDSKSKEGSQNPQSQ, of human Estrogen Receptor, beta.
Cellular LocalizationNuclear
SpecificityRecognizes human estrogen receptor (ER) beta at ~55kD. Species Crossreactivity: rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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