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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -Eukaryotic Translation Initiation Factor 2, alpha (Eukaryotic Translation Initiation Factor 2A, eIF2a, eIF-2A, 65 kD Eukaryotic Translation Initiation Factor 2A, CDA02, MSTP004, MST089, MSTP089)

Anti -Eukaryotic Translation Initiation Factor 2, alpha (Eukaryotic Translation Initiation
Factor 2A, eIF2a, eIF-2A, 65 kD Eukaryotic Translation Initiation Factor 2A, CDA02,
MSTP004, MST089, MSTP089)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Eukaryotic initiation factor 2A (eIF2a) is a 65kD protein that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low [Mg2+]. eIF2a binds initiator tRNA in a GTP-independent manner, but require the presence of the small ribosomal subunit and the trinucleotide start codon, AUG. Phosphorylation of the protein terminates global protein translation and induces apoptosis. human eIF2a gene is localized on chromosome 3q25.1.
Catalog #E8949-01G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochestry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlK562 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human eIF2a around the phosphorylation site of serine 51 (E-L-SP-R-R).
SpecificityRecognizes human eIF2a. Species crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEukaryotic Translation Initiation Factor 2A, 65kDa


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