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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -EIF3M (PCID1, Eukaryotic Translation Initiation Factor 3 Subunit M, eIF3m, Fetal Lung Protein B5, hFL-B5, PCI Domain-containing Protein 1, HFLB5, GA17, PNAS-125)

Anti -EIF3M (PCID1, Eukaryotic Translation Initiation Factor 3 Subunit M, eIF3m, Fetal
Lung Protein B5, hFL-B5, PCI Domain-containing Protein 1, HFLB5, GA17, PNAS-125)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2/GTP/methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).
Catalog #E8949-37T1
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 1-3ug/ml, observed in lysates of human lung carcinoma cell line A549 on ~38-40kD bands
Immunohistochemistry (Paraffin): 5-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-NAWKQNLNKVKN, from human EIF3M, at C-terminal (NP_006351.2).
SpecificityRecognizes human EIF3M. Species sequence homology: Bovine, canine, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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