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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -Eukaryotic Translation Initiation Factor 4E (eIF4E, eIF4EL1)

Anti -Eukaryotic Translation Initiation Factor 4E (eIF4E, eIF4EL1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
eIF4E is a protein that modulates the translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. . Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types.
Catalog #E8949-40L
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.2mg/ml
FormTris-buffered Saline 0.1% BSA
PurityPurified by immunoaffinity chromatography.
ImmunogenAntibody was affinity purified using an epitope specific to eIF4E immobilized on solid support. The epitope recognized by this antibody maps to a region between residue 167 and 217 of human eukaryotic translation initiation factor using the numbering given in entry NP_001959.1 (GeneID 1977).
SpecificitySpecies Crossreactivity: Human and Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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