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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -EIF4E, phosphorylated (Ser209) (Eukaryotic Translation Initiation Factor 4E, eIF4E, eIF-4E, mRNA Cap-binding Protein, eIF-4F 25kD Subunit, EIF4EL1, EIF4F)

Anti -EIF4E, phosphorylated (Ser209) (Eukaryotic Translation Initiation Factor 4E, eIF4E,
eIF-4E, mRNA Cap-binding Protein, eIF-4F 25kD Subunit, EIF4EL1, EIF4F)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.
Catalog #E8949-40N
ApplicationsSuitable for use in ELISA and Dot Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Dot Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acid residues surrounding Ser209 of human EIF4E (KLH).
SpecificityRecognizes human EIF4E when phosphorylated at Ser209.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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