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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -EIF2S1 (Ser51) (Eukaryotic Translation Initiation Factor 2 Subunit 1, Eukaryotic Translation Initiation Factor 2 Subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2A)

Anti -EIF2S1 (Ser51) (Eukaryotic Translation Initiation Factor 2 Subunit 1, Eukaryotic
Translation Initiation Factor 2 Subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2A)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
EIF2 is a translation initiation factor that catalyzes the first regulated step of protein synthesis, promoting the binding of the initiator tRNA to 40s ribosomal subunits. eIF2 is composed of 3 non identical subunits, alpha, beta and gamma. Binding occurs as a ternary complex of methionyl-tRNA, eIF2 and GTP. The rate of complex formation is modulated by the phosphorylation state of eIF2alpha. Phosphorylation of eIF2alpha has been shown to occur in response to heat shock and hypoxic stress. Once eIF2alpha is phosphorylated, the initiation of protein synthesis is inhibited. Expression of eIF-2alpha has been shown to increase in melanoma and colon carcinoma.
Catalog #E9108-48
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to aa surrounding Ser 51 of human EIF2A (KLH).
SpecificityRecognizes human EIF2A. Species sequence homology: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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