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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Factor H (Complement Factor H, Beta 1H)

Anti -Factor H (Complement Factor H, Beta 1H)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH FC
Human complement factor H exists in 2 forms. The most common form, of 150kD, and the less common form of 43kD. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Complement factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.
Catalog #F0010-01B
ApplicationsSuitable for use in ELISA, Immunohistochemistry, Western Blot and Flow Cytometry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Immunohistochemistry Positive ControlKidney from post streptococcal glomerulonephritis patients.
Recommended Secondary AntibodiesI1904-75E: IgG1 (HRP) Pab Rb x Mo
I1904-79M: IgG1 (HRP) Pab Gt x Mo
I1904-75D: IgG1 (FITC) Pab Rb x Mo
I1904-76L: IgG1 (FITC) Pab Gt x Mo
Recommended Negative ControlI1904-78R: IgG1 Murine Negative Control
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No7J1
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in BBS, 0.1% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenPurified human Complement Factor H from serum.
SpecificityRecognizes human Complement Factor H at ~150kD or ~43kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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