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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Factor V

Anti -Factor V

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E
Factor V (formerly referred to as accelerator globulin and labile factor) is a large single chain glycoprotein (330kD) that is produced in the liver. The concentration of FV in bovine plasma is approximately 35ug/ml. FV is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface. Other physiologic activators of FV include plasmin, neutrophil elastase and platelet calpain. The activated cofactor (FVa) is an essential component of the prothrombin activator complex, which consists of FVa, activated factor X, calcium and anionic phospholipid surface. The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold
greater than activated factor X alone. In a positive feedback loop, the thrombin generated accelerates its own generation by activating more FV to FVa. Thrombin also acts to down-regulate FVa indirectly by activating Protein C, which inactivates FVa cofactor activity.
Catalog #F0011-17
ApplicationsSuitable for use in ELISA and immunoelectrophoresis. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceBovine
Concentration~3mg/ml
FormSupplied as a liquid in 10mM HEPES, pH 7.4, 0.15M sodium chloride, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenBovine factor V purified from plasma.
SpecificityRecognizes bovine Factor V as determined by immunoelectrophoresis and ELISA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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