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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Factor VII (F.VII, Stable Factor, Proconvertin)

Anti -Factor VII (F.VII, Stable Factor, Proconvertin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified E B RIA
Coagulation factor VII is synthesized in the liver and circulates in the plasma where it binds to tissue factor (TF) and is rapidly converted into VIIa. The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and also has important coagulation-independent functions such as angiogenesis. The predominant splicing variant of Factor VII in normal liver corresponds to the 444 amino acid precursor. After cleavage of a signal peptide (residues 1 to 38), the mature chain can be further processed into the light chain (residues 39 to 190) and the heavy chain (residues 191 to 444).
Catalog #F0015
ApplicationsSuitable for RIA, ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: Coating: 5-10ug/ml; Secondary: 100-1000ug/ml
Western Blot (Reduced and oxidized forms): 5ug/ml
Optimal dilutions to be determined by the researcher.
Extinction CoefficientE1%, 1cm, 280nm = 14.0
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8.H.3
HostMouse
SourceHuman
Concentration~5mg/ml
FormSupplied as a liquid in ddH2O, 50% glycerol
PurityPurified by gel filtration and ion exchange chromatography.
ImmunogenPurified human Factor VII
SpecificityRecognizes human Factor VII, VIIa, BFPRck Factor VIIa. Does not recognize murine or porcine VII via Western Blot on plasma samples.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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