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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Factor VII (F.VII, Stable Factor, Proconvertin)

Anti -Factor VII (F.VII, Stable Factor, Proconvertin)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Highly Purified E B
Coagulation factor VII is synthesized in the liver and circulates in the plasma where it binds to tissue factor (TF) and is rapidly converted into VIIa. The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and also has important coagulation-independent functions such as angiogenesis. The predominant splicing variant of Factor VII in normal liver corresponds to the 444 amino acid precursor. After cleavage of a signal peptide (residues 1 to 38), the mature chain can be further processed into the light chain (residues 39 to 190) and the heavy chain (residues 191 to 444).
Catalog #F0015-01
ApplicationsSuitable for ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: Recombinant
Western Blot: Recombinant Factor VII or Factor VIIa and native Factor VII (Non-reduced)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No7H80
HostRat
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in 50% glycerol, H2O.
PurityPurified by gel filtration and ion exchange chromatography.
ImmunogenPurified Factor VII.
SpecificityRecognizes mouse Factor VII. Also recognizes VIIa (non-reduced Western Blot only). Species crossreactivity: Does not crossreact with human Factor VII or Factor VIIa.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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