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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified E B

Hemophilia A is an X-linked, recessive, bleeding disorder caused by a deficienty in the activity of coagulation Factor VIII. Affected individuals develop a variable phenotype of hemorrhage into joints and muscles, easy bruising, and prolonged bleeding from wounds. The disorder is caused by heterogeneous mutations in the Factor VIII gene. Up to 30% of hemophilia A patients given therapeutic Factor VIII can make inhibitory antibodies, the majority of which are reactive with its C2 and A2 domains.
Catalog #	F0016-10D
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilutions	Western Blot: Band at ~27kD
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG
Clone No	8k143
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.01% sodium azide.
Purity	Purified
Immunogen	Native purifeid human Factor VIII A2 domain.
Cellular Localization	Extracellular
Specificity	Recognizes human factor VIII and human factor VIIIa in solid-phase ELISA and human factor VIII A2 domain in Western Blot.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.