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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified E B

Hemophilia A is an X-linked, recessive, bleeding disorder caused by a deficienty in the activity of coagulation Factor VIII. Affected individuals develop a variable phenotype of hemorrhage into joints and muscles, easy bruising, and prolonged bleeding from wounds. The disorder is caused by heterogeneous mutations in the Factor VIII gene. Up to 30% of hemophilia A patients given therapeutic Factor VIII can make inhibitory antibodies, the majority of which are reactive with its C2 and A2 domains
Catalog #	F0016-10E
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Hybridoma	NS1 myeloma cells with spleen cells from Balb/c mice.
Storage and Stability	Lyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	9L238
Host	Mouse
Source	Human
Concentration	As reported
Form	Supplied as lyophilized from 10mM sodium phosphate, 0.15M sodium chloride, pH 7.4, 0.01% sodium azide. Reconstitute with 500ul ddH2O.
Purity	Gel filtration and anion exchange chromatograph. 98% pure (SDS-PAGE).
Immunogen	Human Factor VIII A2 domain.
Specificity	Recognizes human factor VIII and human factor VIIIa in solid-phase ELISA and human factor VIII A2 domain in immunoblotting techniques.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.