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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Factor VIII Related Antigen (vWF, Factor VIII Related Antigen)

Anti -Factor VIII Related Antigen (vWF, Factor VIII Related Antigen)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Purified
Von Willebrand Factor (VWF) is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).
Catalog #F0016-13A
ApplicationsSuitable for use in Countercurrent Immunoelectrophoresis (CCIEP) and Radial Immunodiffusion (RID). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in GBS, pH 7.4, 0.1% sodium azide, 0.1% EACA, 0.01% benzamidine, 1mM EDTA.
PurityPurified
ImmunogenHuman Von Willebrand Factor Antigen prepared from citrated human plasma. Cellular Localization: Secreted; located in storage granules.
SpecificityRecognizes human Factor VIII Related Antigen.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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