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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Factor IX

Anti -Factor IX

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Purified E N
Factor IX (FIX, Christmas Factor) is a vitamin K-dependent
glycoprotein produced in the liver. Plasma concentration of FIX
is normally around 5ug/ml (87nM) in plasma. The biological
importance of FIX is demonstrated in Haemophilia B
(Christmas disease). This is an X-linked congenital bleeding disease resulting from a quantitative (low activity and low antigen) or qualitative (low activity and normal antigen) defect in FIX function. In its proenzyme or zymogen form, FIX is a single chain molecule of 55kD. It contains two EGF-like domains and an amino-terminal domain containing 12-g-carboxy-glutamic acid (Gla) residues. These Gla residues allow FIX to bind divalent metal ions and participate in calcium-dependent binding interactions.
Catalog #F0017-08
ApplicationsSuitable for use as ELISA, Neutralization and other solid phase immunoassays for Factor IX and its activation products. Other applications not tested.
Recommended DilutionsELISA: Suitable for use as the capture antibody.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 10mM HEPES, pH7.4, 0.15M sodium chloride, 50% glycerol.
PurityPurified by affinity chromatography.
ImmunogenHuman Factor IX purified from plasma.
SpecificityRecognizes human FIX as analyzed by immunoelectrophoresis and ELISA. Species crossreactivity: porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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