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You are here:Home » Antibodies » Antibodies-Coagulation Factors » Anti -Factor XI

Anti -Factor XI


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Clone Host Grade Applications
Monoclonal Mouse Purified E B RIA
Factor XI is a plasma glycoprotein which circulates in a non-covalent complex with high molecular weight kininogen. The mature molecule is synthesized in the liver and is a two-chain homodimer with a molecular weight of approximately 160,000. It is estimated that 5% of the total mass is attributable to carbohydrate (2). The two identical monomers have molecular weights of 80,000, and are joined together by disulfide bonds. Thus by SDS-PAGE analysis, factor XI appears as a single band both non-reduced (Mr=160,000), and reduced (Mr=80,000). 
Factor XI circulates as a zymogen and requires proteolytic activation to acquire serine protease activity. The conversion of factor XI to factor XIa is catalyzed by factor XIIa, and results in cleavage of the Arg369-Ile370 bond in each monomer. Factor XIa consists of two NH2-terminal derived heavy chains, and two COOH-terminal derived light chains, all of which are held together by disulfide bonds. Factor XIa participates within the intrinsic pathway of coagulation by catalyzing the conversion of factor IX to factor IXa. A bleeding disorder called plasma thromboplastin antecedent deficiency results from a lack of factor XI procoagulant activity. The variable bleeding tendencies observed in factor XI deficient patients do not correlate with either factor XI activity or antigen levels. This latter observation may be related to the ability of the tissue factor/factor VIIa complex to also activate factor IX to IXa. 
Suitable for use in RIA, ELISA and Western Blot. Other applications not tested.
Catalog #F0018-55
Recommended DilutionWestern Blot: 5ug/ml (non-reduced)
Optimal dilutions to be determined by the researcher.
Extinction CoefficientE1%1cm ,280nm = 14.0
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No8.H.6
FormSupplied as a liquid in 50% glycerol, dH2O.
ImmunogenPurified Human Factor XI
SpecificityRecognizes human Factor XI, iodine-125 labeled Factor XI, human
Factor XIa, BEGRck-factor XIa. Does not recognize mouse Factor XI (Western Blot in plasma)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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